I suspect you are not rebinding the data on your update. In the
pageload you mostly are watching for the IsPostBack and not rebinding
the data on the postback, which is a good thing. I could give you an
example of this if you have included the code.

Here is what I have got so far. Don't laught at my code I'm a beginner. I am welcome to any suggestions.

<script runat="server">
 Dim MyConnect As SqlConnection
    Sub Page_Load(Src As Object, E As EventArgs)
        Lbl_Biller.text = session("UserCode")
  Dim ConnectString As String
        MyConnect = New SqlConnection
        connectString = ConfigurationSettings.AppSettings("ConnectStr")
        MyConnect.ConnectionString = ConnectString
        If Not IsPostBack Then
      BindGrid()
      DropDown()
     End If

    End Sub

 public Sub BindGrid()
  Dim strSQL As String
  Dim NewDate as String
        Dim MyCommand As SqlDataAdapter = New SqlDataAdapter ("Select top 5 *  " _
                & "From vBillingQPatient where status= 3", MyConnect)
        Dim BillingQDS As DataSet = New DataSet()
        MyCommand.Fill(BillingQDS,"PatientInfo")
        PatientInfoDataGrid.DataSource=BillingQDS
        PatientInfoDataGrid.DataBind()
  Dim Row1 as datarow = BillingQDS.tables("PatientInfo").Rows(0)
        Dim Row2 as datarow = BillingQDS.tables("PatientInfo").Rows(1) 
  Lbl_BillingQID.Text = Row1("BillingQID").ToString()
  Lbl_PatientName.text = Row1("PatientName").ToString()
  Lbl_Priority.text = Row1("Priority").ToString()
  Lbl_TodayStatus.text = Row1("Status").ToString()
  Lbl_PatientAge.text = Row1("Age").ToString()
  Lbl_DOS.text = Row1("ApptDate").ToString()
  Lbl_ResponsParty.text = Row1("Guarantor1Name").ToString()
  Lbl_PrimaryInsure.text = Row1("PayorName").ToString()
  Lbl_SecInsure.text = Row1("PayorName").ToString()
  Lbl_NextPatient.text = Row2("PatientName").ToString()
    End Sub

 Sub DropDown()
  Dim oReader As SQLDataReader 
  MyConnect.Open()
  Dim MyCommand  = New SqlCommand("Select * From tBillingAction", MyConnect)
        oReader = MyCommand.ExecuteReader()
  BillingActionDropDown.DataSource= oReader
        BillingActionDropDown.DataBind()
 End Sub

 Sub Save_Click(sender As Object, e As EventArgs)
   Dim BillingQHistoryDS As DataSet = New DataSet
   Dim BillingQHistoryCB As SqlCommandBuilder
      Dim ConnectString As String
      Dim Connect As SqlConnection = New SqlConnection
      Dim Adapter As SqlDataAdapter = New SqlDataAdapter
   Dim Row as DataRow
   ConnectString = ConfigurationSettings.AppSettings("ConnectStr")
            Connect.ConnectionString = ConnectString
            Adapter.SelectCommand = New SqlCommand("Select * from tBillingQHistory",Connect)
            BillingQHistoryCB = New SqlCommandBuilder(Adapter)
            Adapter.Fill(BillingQHistoryDS,"BQHistory")
   Row = BillingQHistoryDS.Tables("BQHistory").NewRow
            Row.Item("UserID") = Lbl_Biller.text
            Row.Item("Date") = Format(Now,"d")
            Row.Item("BillingAction") = BillingActionDropDown.selectedItem.Value
      BillingQHistoryDS.Tables("BQHistory").Rows.Add(Row)
            adapter.Update(BillingQHistoryDS, "BQHistory")
      If BillingQHistoryDS.HasErrors Then
                Lbl_Message.text = "There was an error inserting new Billing Action." & _
                                BillingQHistoryDS.Tables("BQHistory").Rows(0).RowError
            End If
   'Update Status
   UpdatePatient()

 End Sub

 Sub UpdatePatient()
   Dim BillingQDS As DataSet = New DataSet
   Dim BillingQCB As SqlCommandBuilder
      Dim ConnectString1 As String
      Dim Connect1 As SqlConnection = New SqlConnection
      Dim Adapter1 As SqlDataAdapter = New SqlDataAdapter
   Dim Row1 as DataRow
   ConnectString1 = ConfigurationSettings.AppSettings("ConnectStr")
   Connect1.ConnectionString = ConnectString1
   Adapter1.SelectCommand = New SqlCommand("Select * from tBillingQ where BillingQID =" & Lbl_BillingQID.text  , Connect1)
   BillingQCB = New SqlCommandBuilder(Adapter1)
   Adapter1.Fill(BillingQDS,"BillingQ")
   Row1 = BillingQDS.Tables("BillingQ").Rows(0)
   Row1.Item("Status") = 1
   Adapter1.Update(BillingQDS,"BillingQ")

   If BillingQDS.HasErrors Then
   Lbl_Message.text = "There was an error Updating this user account." & _
       BillingQDS.Tables("BillingQ").Rows(0).RowError
   End If
 End Sub

 Sub ActLog_Click(sender As Object, e As EventArgs)
  Dim sScript as String 
          sScript = "<script language=JavaScript> " 
          sScript += "window.open('http://Griffster/pace/BillingActionLog.aspx', 'newWin','scrollbars=yes,status=no,width=700,height=400');<"
          sScript += "/script>"

          If ( Not IsClientScriptBlockRegistered("GotoActionLogScript")) Then
              RegisterClientScriptBlock("GotoActionLogScript", sScript)
          End If
 End Sub
</script>